环境毒素调节了儿科代谢功能障碍相关的脂肪肝炎的疾病严重程度
Ajay K Jain1, Stefanie A Busgang2, Chris Gennings2
1Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Saint Louis University, St. Louis, Missouri, USA.
Journal of pediatric gastroenterology and nutrition
|September 16, 2024
概括
像PFAS和PBDE这样的环境毒素与儿科代谢功能障碍相关的脂肪肝炎 (MASH) 有相反的关联. 特定的代谢物与MASH有关,为未来儿童治疗和诊断提供了洞察力.
科学领域:
- 儿科肝病学 儿科肝病学
- 环境毒理学环境毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在儿童中很普遍.
- 从MASLD到代谢功能障碍相关的脂肪肝炎 (MASH) 的进展可能受到环境因素的影响.
研究的目的:
- 研究血清环境毒素和代谢物与MASLD向MASH在儿童中的进展之间的关联.
- 在儿科队列中识别与MASH相关的特定毒素和代谢概况.
主要方法:
- 从435名患有组织学确认的MASLD或MASH的儿童的血清样本中分析了 perfluoroalkyl物质 (PFAS),多化二乙烯 (PBDE) 和代谢物.
- 使用加权定量总回归 (WQSrh) 和后勤回归模型来评估关联.
- 代谢数据使用随机子集WQSrh方法,因为预测因素的数量很高.
主要成果:
- 在PFAS/PBDE混合物和MASH之间观察到一个反向的关联,特别是由 perfluorohexane sulfonate (PFHXS) 驱动.
- 这种混合物与分叶炎症,非酒精性稳定性肝炎评分 (NAS) 和氨酸转移酶 (ALT) 水平相反相关.
- 特定的代谢物,包括比利弗丁,1-甲基希斯蒂丁和希普酸,与MASH有显著的关联.
结论:
- 由PFHXS主导的PFAS/PBDE混合物显示出对儿童MASH的保护作用.
- 已识别的代谢物提供了潜在的机理性见解,并可能为儿童MASH的新疗法和诊断策略的开发提供信息.
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