尼泊尔重大抑郁症的遗传架构和社会环境风险因素
Karmel W Choi1,2,3, Justin D Tubbs1,2,3, Younga H Lee1,2,3
1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Psychological medicine
|September 16, 2024
概括
在尼泊尔,主要抑郁症的遗传率为0.26,与欧洲研究相似. 然而,在欧洲人群中开发的多基因分数没有预测尼泊尔人样本中的抑郁风险,突出了与祖先有关的遗传差异.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 全球健康 全球健康
背景情况:
- 大型抑郁症 (MDD) 是全球导致残疾的主要原因.
- 现有的遗传研究主要以欧洲为中心,限制了诸如多基因分数 (PGS) 等发现的可移植性.
- 了解跨不同祖先的MDD遗传结构对于公平的健康进步至关重要.
研究的目的:
- 在一个尼泊尔家庭的样本中调查MDD的遗传结构.
- 评估在尼泊尔MDD的欧洲和东亚数据上训练的多基因分数 (PGS) 的预测能力.
- 在这个代表性不足的人群中检查MDD的社会环境相关性.
主要方法:
- 基于基因组的限制最大概率 (GREML) 用于估计MDD遗传性.
- 使用S-LDXR. 的方法估计了跨祖先的遗传相关性.
- 多基因分数 (PGS) 是使用GWAS对欧洲和东亚祖先的元分析数据来建模的.
主要成果:
- 在尼泊尔样本中,终身MDD的狭义遗传率估计为0.26.
- 分析不足以对跨祖先遗传相关性进行可靠估计 (rg = 0.26).
- 患MDD的风险与年龄,女性性别和童年创伤有关,但与抑郁症PGS或其与童年创伤的相互作用无关.
结论:
- 尼泊尔MDD的遗传概率估计与欧洲人群的遗传概率相当.
- 来自欧洲祖先数据的多基因分数显示,尼泊尔样本中MDD的预测效用有限.
- 差异可能源于祖先相关的遗传变异,表型差异或环境因素,这凸显了在全球多样化人口中进行研究的必要性.
相关概念视频
Depressive Disorders: Etiology
58
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
58
Human Genetics
547
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
547
Psychological and Sociocultural Causes of Schizophrenia
81
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
81
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Gene-Environment Interactions
270
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
270
Behavioral Genetics and Its Designs
344
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
344


