斯格罗马布用于治疗癌症 卡切西亚
John D Groarke1, Jeffrey Crawford1, Susie M Collins1
1From the Internal Medicine Research Unit (J.D.G., I.K., M.A.H., A.R.S.) and Clinical Pharmacology (R.Q.), Pfizer, Cambridge, MA; Duke Cancer Institute, Duke University Medical Center, Durham, NC (J.C.); Global Biometrics and Data Management, Pfizer R&D UK, Sandwich (S.M.C.), and Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh (M.F.) - both in the United Kingdom; Translational Clinical Sciences, Pfizer, Collegeville, PA (S.L.); Knight Cancer Institute, Oregon Health and Science University, Portland (E.J.R.); the Cancer Supportive Care Center, Shizuoka Cancer Center, Shizuoka (T.N.), and the Department of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Kyoto (K.T.) - both in Japan; Cedars-Sinai Medical Center, Los Angeles (A.E.H.); the Ottawa Hospital Cancer Centre, Ottawa (T.A.); Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY (R.F.D.); Translational Clinical Sciences, Pfizer, Groton, CT (C.A.N.); and the Internal Medicine Research Unit, Pfizer, Tampa, FL (M.R.).
庞斯格罗马布是一种针对生长分化因子15 (GDF-15) 的抗体,有效增加了癌症缓解症患者的体重和改善了活动. 这项研究证实GDF-15驱动癌症缓解症,提供了一个新的治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 癌症缓冲症是一种衰弱的疾病,与增加的死亡率有关.
- 细胞因子生长分化因子15 (GDF-15) 的水平升高是癌症缓存症的特征.
- 预先的研究表明,GDF-15抑制剂ponsegromab可以改善缓冲症的症状.
研究的目的:
- 评估ponsegromab在治疗癌症缓解症中的疗效和安全性.
- 评估ponsegromab对癌症缓解症患者的体重,食欲和身体活动的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂控制的第二阶段试验.
- 187名患有癌症缓解症和血清GDF-15水平升高的患者随机分别接受ponsegromab (100 mg,200 mg或400 mg) 或安慰剂每4周一次皮下注射.
- 主要终点:12周体重变化;次要终点:食欲,缓解症症状,体力活动和安全性.
主要成果:
- 与安慰剂相比,Ponsegromab治疗在所有测试剂量中导致显著的体重增加.
- 服用400毫克的剂量显著改善了食欲,缓冲症症状和身体活动.
- 庞塞格罗马布和安慰剂组之间的不良事件是可比的,分别有70%和80%的事件报告.
结论:
- 用ponsegromab抑制GDF-15是一种有效的策略,用于增加癌症缓解症患者的体重增加和改善活动水平.
- 这些发现证实了GDF-15作为癌症缓解症的关键驱动因素的作用.
- 庞塞格罗马布表现出良好的安全性,支持其作为治疗剂的潜力.
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