怀孕早期的BMI,孕期体重增加,以及儿童喘和过敏性疾病
Vincent Ojwang'1,2,3, Bright I Nwaru1,4,5, Takkinen Hanna-Mari1,6,7
1Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland.
概括
在怀孕早期,母亲的妊娠期体重增加 (GWG) 可能会增加孩子患亚托皮性湿疹的风险. 然而,无论是怀孕早期的体重指数 (BMI) 还是GWG都没有显示出与儿童喘或其他过敏疾病的明显联系.
科学领域:
- 产科和妇科 产科和妇科
- 儿科过敏和免疫学
- 公共卫生 公共卫生
背景情况:
- 怀孕早期体重指数 (BMI) 和孕期体重增加 (GWG) 与儿童喘和过敏疾病之间的关系尚不清楚.
- 现有研究提出了不一致的发现,需要对这些关联进行进一步调查.
研究的目的:
- 调查早期怀孕BMI和GWG与5岁以下儿童喘和过敏疾病发病率之间的联系.
- 探索怀孕期间母亲体重管理与后代过敏症发展之间的潜在联系.
主要方法:
- 分析了一项前性出生队列研究的数据,该研究涉及3176对母婴.
- 计算早期怀孕的BMI和GWG,使用母体人类测量测量.
- 通过验证的问卷和IgE抗体分析,对儿童喘和过敏性疾病 (疹,过敏敏感,过敏性鼻炎) 的评估,直到5岁.
- 应用考克斯的比例危险和物流回归模型来确定关联.
主要成果:
- 在怀孕早期的BMI或GWG (作为连续变量) 与儿童喘或过敏疾病之间没有发现显著的关联.
- 然而,与第一季度相比,在母亲处于GWG第三季度的儿童中,在5岁时患上阿托皮性湿疹的几率明显更高 (调整后OR1.49,95%CI [1.13-1.96]).
结论:
- 怀孕早期的BMI,GWG和儿童喘和过敏疾病之间的关联是不一致的.
- 增加的母体GWG,特别是在妊娠的第三季度,可能与儿童疹风险增加有关.
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