少了就是多了吗? 一个审查的psilocybin微剂量
Isabella A Savides1, Kim Outhoff1
1Department of Pharmacology, University of Pretoria, Pretoria, Gauteng, South Africa.
Journal of psychopharmacology (Oxford, England)
|September 16, 2024
概括
微剂量psilocybin的研究是有限的,只有少数临床试验. 需要更多的研究来了解它的有效性和安全性,重点是安慰剂对照试验和多样化的人群.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 心理健康研究 心理健康研究
背景情况:
- 魔法中的一种化合物psilocybin正在探索微剂量.
- 微剂量涉及潜在益处的次幻觉剂量,而不会引起感知扭曲.
- 目前的psilocybin微剂量研究还处于起步阶段,存在重大局限性和知识差距.
研究的目的:
- 系统地审查和识别psilocybin微剂量的关键研究缺口.
- 引导未来在这个新兴领域的科学研究.
主要方法:
- 使用PRISMA指南和跨数据库的关键词搜索进行系统审查.
- 包括谷歌搜索灰色文献,确定了40项研究和8个网站.
- 将证据分类为非临床,临床,观察和事.
主要成果:
- 大多数证据来自观察性研究;临床和非临床数据稀少且不一致.
- 确定了关键的研究缺陷,包括需要随机的安慰剂对照试验,剂量反应研究和多样化的参与者群体.
- 强调需要使用活性安慰剂,心理评估,单独使用西宾的研究,以及改进动物模型.
结论:
- 目前,关于 пси洛西宾微剂量疗效的最终结论是难以捉摸的.
- 许多研究缺口需要在未来的科学努力中集中注意力.
- 进一步严格的研究是必要的,以确定psilocybin微剂量的安全性和有效性.
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