在可变翻转角度和修改的Look-Locker倒置恢复之间进行比较研究,以评估间纤维化
Chenchen Hua1, Yi Zhuang2, Miaoyan Wang2
1Department of Diagnostic Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Journal of magnetic resonance imaging : JMRI
|September 16, 2024
概括
可变翻转角度 (VFA) 和修改的看锁反转恢复 (MOLLI) 两种方法都有效地评估慢性病中的间纤维化. 皮层甲状腺T1值在两种T1映射方法之间没有显著差异.
科学领域:
- 磁共振成像是一种磁共振成像技术.
- 腎臟病學 (nephrology) 是一種醫學.
- 放射学 放射学是一门学科.
背景情况:
- 慢性病 (CKD) 的评估通常包括评估间位纤维化 (IF).
- 可变翻转角度 (VFA) 和修改的看锁反转恢复 (MOLLI) 是用于非侵入性IF评估的常见T1映射技术.
- 需要对VFA和MOLLI进行直接比较,以便对脏IF进行评估.
研究的目的:
- 为了比较VFA和MOLLI对T1映射的诊断疗效,评估脏IF.
- 为了确定VFA或MOLLI是否优于评估慢性病患者的间纤维化.
主要方法:
- 这是一项前性研究,涉及51名CKD患者和18名健康志愿者.
- 使用VFA (3D梯度回声) 和MOLLI (2D梯度回声) 序列的3.0T MRI进行T1映射.
- 图像质量,T1值 (皮质,脑髓),皮质骨髓T1差异 (ΔT1) 和比率 (T1比率) 被分析并与活检证明的IF等级相关联.
主要成果:
- 莫利显示出明显更好的图像质量比VFA.
- 虽然VFA和MOLLI之间的绝对皮质和脑髓T1值有显著差异,但皮质骨髓T1差异 (ΔT1) 和比率 (T1比率) 没有显著差异.
- 在VFA和MOLLI T1映射方法之间,没有观察到VFA和MOLLI T1映射方法之间的脏IF的诊断性能有显著差异.
结论:
- 无论是VFA还是MOLLI,都有效用于对脏间歇性纤维化进行非侵入性评估.
- 在VFA和MOLLI之间,皮膜膜T1差异和比率是可比的,这表明IF评估的可互换性.
- 进一步的研究可能会探索特定病理的最佳序列.
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