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Updated: Jun 13, 2025

Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction
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在CBC-ALYREF复合体的冷-EM结构

Bradley P Clarke1, Alexia E Angelos1, Menghan Mei1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.

eLife
|September 16, 2024
PubMed
概括

核结合复合体 (CBC) 招募mRNA出口因子,如ALYREF. 这项研究揭示了CBC-ALYREF结构,详细介绍了ALYREF如何与CBC相互作用以促进mRNA出口.

关键词:
阿里雷夫 (Alyref) 是一个名为阿里雷夫 (Alyref) 的名字.这是TREX.盖帽结合复杂的复杂的结合.人类 人类 人类 人类 人类 人类 人类核出口mRNA的核出口分子生物物理学分子生物物理学结构生物学结构生物学

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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