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结直肠癌建模的进展和挑战以及对新药发现的影响

Natália Teixeira^1,2,3, Ana Baião^1,2,3, Sofia Dias^1,2,3

¹i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Expert opinion on drug discovery

|September 16, 2024

概括

先进的3D模型提供了比2D系统更好的结肠直肠癌 (CRC) 研究能力. 新的3D生物打印和芯片模型更好地模仿瘤微环境,以提高药物发现.

科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
癌症研究癌症研究

背景情况:

结肠直肠癌 (CRC) 是一个主要的全球健康问题,转移性疾病的生存率很低.
传统的二维细胞培养不能复制复杂的瘤微环境 (TME).
癌症是一种复杂,异质的疾病,受遗传,表观遗传和环境因素的影响.

研究的目的:

探索结直肠癌 (CRC) 研究模型的演变.
突出3D模型的进步,包括生物打印和芯片上系统.
讨论新型CRC建模技术的潜力和挑战.

主要方法:

审查传统的二维细胞培养限制.
探索先进的3D结肠直肠癌 (CRC) 模型.
讨论3D生物打印和芯片上的CRC模型,以模拟体内条件.

主要成果:

3D模型为CRC研究提供了相对于2D系统的显著改进.
3D生物打印和芯片上模型增强模拟体内条件的能力.
先进的模型显示出开发患者特异性结肠直肠癌 (CRC) 研究工具的前景.

结论:

过渡到3D模型标志着结直肠癌 (CRC) 研究的关键转变.
针对患者的3D模型有望更好地模仿体内条件.
仍然存在挑战,包括复杂性,成本和标准化,以便广泛采用先进的CRC模型.

关键词:

大肠直肠癌模型患者获得的瘤器官三维生物打印三维生物印刷发现药物的发现.瘤微环境是一个微环境.

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