在皮秒激光治疗后,在梅拉斯马患者中调节黑色素细胞
Ching-Li Chen1,2, Chih-Chiang Chen1,2,3,4, Feng-Ling Tsai5
1Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal of cosmetic dermatology
|September 16, 2024
概括
激光治疗通过减少病变区域,改善了瘤的严重程度. 光学连贯断层扫描 (OCT) 没有显示出黑色素变化,但显示了黑色素细胞长度和宽度的减少.
科学领域:
- 皮肤病学 皮肤病学
- 医疗成像医学成像
- 组织病理学 组织病理学
背景情况:
- 黑色素是一种难以治疗的多颜色化疾病.
- 在激光治疗后对黑色素和黑色素细胞变化的体内研究有限.
研究的目的:
- 在激光治疗前后使用光学连贯断层扫描 (OCT) 来研究瘤中黑色素和黑色素细胞的变化.
- 为了将OCT发现与临床改进相关联.
主要方法:
- 八名女性乳腺瘤患者接受了激光治疗.
- 光学连贯断层扫描 (OCT) 在基线,第4周和第8周对瘤病变和正常皮肤的成像.
- 根据患者的黑色素瘤类型 (表皮或混合) 分类,以进行量身定制的治疗.
主要成果:
- 梅拉斯马区域严重性指数 (MASI) 评分在8周后显著改善 (10.92至6.30).
- 海外国家和地区在黑色素密度,面积或强度上没有显著变化.
- 树突性黑色素细胞的长度减少以与正常皮肤相匹配,并且在损伤皮肤中观察到宽度的减少.
结论:
- 激光治疗有效地改善了瘤的严重程度,主要是由于减少了病变面积.
- OCT没有显示出黑色素的显著变化,但表明树突性黑色素细胞大小减少.
- 这些发现表明,激光疗法在治疗瘤时影响了黑色素细胞形态学.
相关概念视频
Pigmentation
3.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.8K
Changes in Skin Color: Clinical Perspectives
3.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.6K
Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K


