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Updated: Jun 13, 2025

Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis
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通过减少质子转移电荷的方法对抗体进行中下分析的通用方法 - 轨道质谱质谱法

Ryan N Oates1, Linda B Lieu1, Jake T Kline2

  • 1Department Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73109, USA.

Analytical and bioanalytical chemistry
|September 16, 2024
PubMed
概括

质子转移电荷减小 (PTCR) 简化了单克隆抗体 (mAb) 子单元测序的中向下质谱学 (MD MS). 这种技术增强了碎片离子分配,并增加了对mAbs.序列覆盖的信心.

关键词:
在ETDD时刻.EThcD 在线观看里叶变换质谱学,FTMS, 电磁波谱学这是一个HCD,HCD是HCD.在IgG IgG的基础上.在中下,中下.一个单克隆抗体,mAb轨道上的陷轨道陷日食的发生减少质子转移电荷,PTCR.

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