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Updated: Jun 13, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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范科米辛在患有囊性纤维化的儿科患者中:使用人口药动力学方法进行剂量优化

Aysenur Yaliniz1,2, Mathieu Blouin3,4, Marie-Élaine Métras4,5

  • 1STP2 Laboratory, Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada. aysenur.yaliniz@umontreal.ca.

European journal of drug metabolism and pharmacokinetics
|September 16, 2024
PubMed
概括

儿童囊性纤维化 (CF) 患者的万科米辛剂量需要仔细监测. 这项研究评估了人群药理动力学 (popPK) 模型,以找到最佳的万科米辛疗法,突出了临床使用前需要外部验证的必要性.

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