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在非前列腺恶性瘤中ETS转位:在胸腺癌和肺腺癌中发现了一个意想不到的发现

Kamilla Németh¹, László Báthory-Fülöp^1,2, Andrea Kohánka¹

¹Department of Surgical and Molecular Pathology, National Institute of Oncology, Budapest, Hungary.

Virchows Archiv : an international journal of pathology

|September 16, 2024

概括

TMPRSS2::ETS融合在前列腺癌中很常见,但在其他瘤中很少见. 研究人员在两个非前列腺癌中发现了这些融合,强调了诊断时需要谨慎.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

TMPRSS2::ETS融合是前列腺腺癌的标志,经常用于诊断.
这些融合在非前列腺恶性瘤中的患病率尚未得到充分确立.

研究的目的:

调查TMPRSS2::ETS融合在包括非前列腺恶性瘤在内的大量固体瘤队列中的频率.
确定这些融合是否发生在前列腺癌之外,并评估诊断影响.

主要方法:

使用下一代测序面板对1758个固体瘤进行查,以检测TMPRSS2::ETS融合.
在分析中包括1690种非前列腺恶性瘤.

主要成果:

在68种前列腺腺癌中的28种中确定了TMPRSS2::ETS融合.
在两个非前列腺瘤中检测到融合:TMPRSS2::ETV1在胸腺状细胞癌中和TMPRSS2::ERG在肺腺癌中.
两个非前列腺癌患者都是男性,这表明潜在的雄激素驱动的背景.

结论:

TMPRSS2::ETS融合虽然是前列腺癌的特征,但在非前列腺瘤中可能发生的频率很低.
单独依赖TMPRSS2:ETS融合识别可能导致非前列腺恶性瘤的诊断错误.

关键词:

分子诊断学分子诊断学下一代测序测序是什么前列腺腺癌前列腺腺癌.TMPRSS2::ETS 核聚变系统的第二个版本

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