在患有固体瘤的患者中,通过外周血液衍生的PD-1/CD28-CD19CAR修饰的PD-1+T细胞疗法

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Zhen Zhang1, Xuan Zhao1, Qitai Zhao1

  • 1Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Cancer immunology research
|September 16, 2024
PubMed
概括

经过修改的外周血液T细胞表达编程细胞死亡1 (PD-1) 显示在癌症患者中增强了抗瘤活性和安全性,提供了一种有前途的新细胞治疗方法.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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