人类大脑的嗅觉球中的微塑料
Luís Fernando Amato-Lourenço1,2, Katia Cristina Dantas2, Gabriel Ribeiro Júnior2
1Institute of Biology, Freie Universität Berlin, Berlin, Germany.
JAMA network open
|September 16, 2024
概括
在人类的嗅觉球泡中发现了微塑料,这表明它可能是通往大脑的途径. 这一发现凸显了对微塑料 (MP) 神经毒性和大脑进入机制的更多研究的需要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
背景情况:
- 微塑料 (MP) 污染是一个日益严重的全球性问题,可能会对健康产生影响.
- 虽然在各种人体组织中发现了MPs,但它们在大脑中的存在在很大程度上仍未得到记录.
- 了解MP转移到大脑对于评估神经毒性风险至关重要.
研究的目的:
- 为了调查人类嗅觉球泡中微塑料 (MPs) 的存在.
- 描述检测到的MPs的物理和化学特性.
- 探索MP进入人类大脑的潜在途径.
主要方法:
- 涉及15名已故个体的嗅球组织的案例系列研究.
- 使用直接检查和消化组织过的组织分析.
- 通过微里埃变换红外光谱学识别和描述MPs.
主要成果:
- 在15个个体中,有8个个体的嗅觉球体中检测到微塑料 (MP).
- 共有16种合成聚合物颗粒和纤维被确定,主要是聚烯.
- 粒子的MP大小从5.5μm到26.4μm不等,平均纤维长度为21.4μm.
结论:
- 这项研究提供了MPs在人类嗅觉球中的第一个证据.
- 嗅球可以作为MP转移到大脑的途径.
- 进一步的研究是必要的,以了解MPs的神经毒性作用和大脑屏障透.
更多相关视频
04:00Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
Published on: September 13, 2024
768
08:30Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
Published on: October 31, 2011
16.0K
相关概念视频
01:20Physiology of Smell and Olfactory Pathway
8.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.2K
01:03Olfactory Receptors: Location and Structure
9.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.1K
01:25Olfaction
44.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.2K