亚临床甲状腺功能障碍和心血管疾病
Hye Jeong Kim1,2, Donald S A McLeod2,3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
Thyroid : official journal of the American Thyroid Association
|September 16, 2024
概括
亚临床甲状腺功能障碍症 (SCHyper) 会增加心血管疾病 (CVD) 的风险,包括心房动和心力衰竭. 对于SCHyper的治疗决定,应考虑TSH水平和患者年龄,以实现个性化的心血管风险管理.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 亚临床甲状腺功能障碍症 (SCHyper) 的特征是甲状腺刺激激素 (TSH) 水平较低,没有明显的症状.
- 越来越多的证据表明SCHyper和不良心血管结果之间存在联系.
研究的目的:
- 审查和综合有关SCHyper与一般人群中心血管疾病 (CVD) 相关的已公布数据.
- 评估特定心血管疾病结局的风险,包括心房动,心力衰竭,中风,冠心病,主要心脏不良事件和死亡率.
主要方法:
- 现有文献的叙述性审查.
- 对SCHyper数据的分析及其与各种心血管疾病风险因素和事件的相关性.
主要成果:
- SCHyper与心房动,心力衰竭,主要心脏不良事件 (MACE),心血管死亡率和全因死亡率的风险增加有关.
- 与较低的TSH水平 (0.1-0.4 mIU/L) 相比,更低的TSH水平 (<0.1 mIU/L) 的心血管疾病风险更高.
- 对于冠心病风险存在相互矛盾的结果,有限的证据将SCHyper与中风风险或与年龄相关的心血管疾病风险增加联系起来.
结论:
- SCHyper与显著的心血管风险有关,特别是心房动和心力衰竭.
- 对SCHyper的个性化治疗策略至关重要,考虑到TSH抑制程度和患者年龄是心血管疾病的关键风险因素.
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