甲状腺功能,糖尿病和常见的与年龄相关的眼睛疾病:孟德尔的随机化研究
Christina Ellervik1,2,3,4, Lena Boulakh5, Alexander Teumer6,7
1Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thyroid : official journal of the American Thyroid Association
|September 16, 2024
概括
自身免疫性甲状腺疾病 (AITD) 增加了糖尿病视网膜病变和白内障的风险,主要是通过1型糖尿病 (T1D). 在正常范围内较高的自由甲状腺素 (FT4) 水平与晚年相关的黄斑变性 (AMD) 有关,特别是在女性中.
科学领域:
- 眼科和内分泌学 遗传学 遗传学
- 使用门德尔随机化 (MR) 探索甲状腺功能与与年龄相关的眼睛疾病之间的因果关系.
背景情况:
- 以前的MR研究表明甲状腺功能低下症和白内障之间存在关联,以及高正常的自由甲状腺素 (FT4) 和与晚年相关的黄斑变性 (AMD).
- 在自身免疫性甲状腺疾病 (AITD),青光眼,双向因果关系,多变量MR (MVMR),性别差异和糖尿病调解方面存在差距.
研究的目的:
- 调查AITD,FT4/TSH在参考范围内的因果关系和方向性,以及常见的与年龄有关的眼病.
- 检查1型糖尿病 (T1D) 和2型糖尿病 (T2D) 在这些关联中的调解作用.
- 探索FT4-AMD链接中的潜在性别差异.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 总结统计数据进行了双向的双样本门德尔随机化 (MR) 研究.
- 使用多变量MR (MVMR) 来评估独立的因果关系影响.
- 研究T1D和T2D作为潜在的调解者.
主要成果:
- 对AITD的遗传倾向与糖尿病视网膜病变,白内障和T1D的风险增加有关,但T2D的风险较小.
- MVMR表明T1D调解了AITD对糖尿病视网膜病变和白内障的影响.
- 在参考范围内的更高的基因预测FT4与晚期AMD风险增加相关,特别是在女性中. 在AITD,T1D和糖尿病视网膜病变之间发现了双向关联.
结论:
- 对AITD的遗传倾向有助于糖尿病视网膜病变和白内障的风险,主要是通过T1D.
- AITD,T1D和糖尿病视网膜病变之间的相互关联表明共享的自身免疫病因.
- FT4和晚期AMD之间的关联,以及潜在的性别特异性影响,需要进一步调查.
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