在儿科患者群体中,孔卡布洛萨的患病率
Jessie G Jiang1, Sarah A Gitomer2, Suhong Tong3
1University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO, 80045, USA.
International journal of pediatric otorhinolaryngology
|September 16, 2024
概括
Concha bullosa (CB) 是一个充满空气的中间轮,影响了近40%的4岁以上的儿童. 这种常见的发现通常与鼻腔隔膜偏差有关,特别是在相反的侧面.
科学领域:
- 儿科放射学 儿科放射学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 人体解剖学 解剖学 解剖学
背景情况:
- 中间轮的气动化,称为concha bullosa (CB),是一种解剖学变异,在儿科群体中流行率数据有限.
- CB具有临床意义,因为它可以影响鼻腔解剖学,并且经常与先天性鼻腔隔膜偏差 (SD) 相关.
研究的目的:
- 使用头部成像来确定小儿科队列中孔卡布洛萨 (CB) 的患病率.
- 描述CB的常见类型及其与儿童鼻隔膜偏差 (SD) 的关联.
主要方法:
- 进行了对695个儿科CT头部扫描创伤 (2021-2022) 的回顾性审查.
- 排除标准包括面部骨折,鼻炎,综合征,之前的手术和鼻质.
- 两个儿科神经放射学家评估了384个符合条件的扫描,将CB定义为中轮的垂直高度>50%的通风.
主要成果:
- 在被研究的儿科人口中,CB的患病率为39.8%,在4岁以上的儿童中显著更高 (p < 0.0001).
- 状型CB是最常见的亚型,在20.8%的中间轮机中发现.
- 鼻隔膜偏差 (SD) 在39.2%的CB患者中存在,主要与CB相反.
结论:
- 儿童中CB的患病率处于成人报告的较低范围之内.
- 状CB是儿科患者中观察到的最常见的类型.
- 在CB和逆向SD之间存在显著的关联,CB和SD的严重程度之间存在正相关性.
相关概念视频
01:49Probability Laws
Overview
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...