帕雷科克西布对术后认知功能和镇痛安全性的影响在接受胃肠道瘤切除的老年患者中:一项回顾性研究
1Department of Anesthesiology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China; Department of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, China.
Biomolecules & biomedicine
|September 16, 2024
概括
帕雷科克西布在老年胃肠道癌症患者中有效降低了术后疼痛,而不会增加认知功能障碍或并发症. 这表明帕雷科克西布是大手术后疼痛管理的安全选择.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 在瘤学瘤学.
背景情况:
- 神经炎症与术后认知功能障碍 (POCD) 有关.
- 帕雷科西布是一种强大的抗炎和止痛药,可以减轻POCD.
- 接受胃肠道癌症手术的老年患者有POCD和疼痛的风险.
研究的目的:
- 调查帕雷科克西布是否可以降低POCD发生率和老年胃肠道癌症患者的术后疼痛.
- 评估帕雷科克西布是否会增加这一组患者的术后并发症.
主要方法:
- 一项涉及440名接受选择性胃肠道瘤切除的老年患者的比较研究.
- 患者被划分为接受帕雷科克西布 (NSAIDs组) 或不接受 (非NSAIDs组) 的组.
- 主要结局:7天内POCD发病率;次要结局:术后疼痛水平和不良事件.
主要成果:
- 在两组之间,POCD的发病率相似 (42.60%vs. 40.30%,P > 0.05).
- 而NSAIDs组在术后第1天和第2天的疼痛显著减少 (P<0.05).
- 两组之间没有观察到术后不良事件的显著差异 (P > 0.05).
结论:
- 在接受重大胃肠道手术的老年患者中,帕雷科克西布有效地缓解了早期的术后急性疼痛.
- 帕雷科克西布似乎不会对早期术后认知功能产生负面影响或增加并发症.
- 研究结果支持在这个脆弱人群中使用帕雷科克西布治疗术后疼痛.
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