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在中国的HIV-1 CRF59_01B分子,传播特征,起源和动态分析:一个分子流行病学研究研究

Yefei Luo¹, Hao Wu¹, Caiyun Liang¹

¹Department of AIDS control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, People's Republic of China.

|September 16, 2024

概括

中国的HIV-1 CRF59_01B流行病起源于1992年左右的中国东南部,并在区域范围内蔓延. 基于它的时空动态和传输网络,可以制定有针对性的预防策略.

科学领域:

流行病学流行病学
病毒学病毒学
公共卫生公共卫生

背景情况:

人类免疫缺陷病毒1型 (HIV-1) 循环复合形式59_01B (CRF59_01B) 是一个具有显著的亚型,具有不断变化的流行病模式.
了解其时空动态和传输网络对于中国有效的控制战略至关重要.

研究的目的:

为了研究中国HIV-1 CRF59_01B流行病的时空动态.
为了阐明HIV-1 CRF59_01B在中国的传播网络和起源.

主要方法:

从2007年至2020年期间从中国10个省份收集的250个HIV-1 CRF59_01B多基因序列的家族遗传学分析.
贝叶斯天际线和出生死亡模型的应用,用于植物动力学分析和分子网络分析,以确定传输集群.

主要成果:

确定了45个传输集群,其中62.40%的序列属于这些集群.
人类地理分析表明,中国东南地区是HIV-1 CRF59_01B的最可能来源地,随后传播到其他地区.
从2000年到2015年,CRF59_01B的有效种群规模有所增加,大集群从2013年到2020年持续增长.

结论:

该研究成功地绘制了HIV-1 CRF59_01B在中国的时间和地理起源.
了解跨地区和风险群体的传播途径,有助于制定有针对性的艾滋病毒预防策略.

关键词:

在CRF59_01B中使用.艾滋病病毒-1 艾滋病病毒-1 分子流行病学分子流行病学植物动力学学.植物地理学植物地理学传输集群是一个传输集群.

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