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在患有原发性阿尔多斯特罗尼斯症的患者中,正常张力玻璃眼的患病率
Kazuyuki Hirooka1, Tomomi Higashide2, Kimikazu Sakaguchi2
1From the Department of Ophthalmology and Visual Science, (K.H., T.B., Y.K.), Hiroshima University, Hiroshima, Japan.
American journal of ophthalmology
|September 16, 2024
概括
原发性阿尔多斯特龙症 (PA) 患者有11.8%的正常张力玻璃眼 (NTG) 患病率. 这些患者面临NTG的风险较高,独立于血压水平.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
背景情况:
- 初级阿尔多斯子主义 (PA) 是一种因过度生产阿尔多斯子而表现的病症.
- 玻璃眼,特别是正常张力玻璃眼 (NTG),是不可逆转的失明的主要原因.
- 需要进一步调查PA和NTG之间的关系.
研究的目的:
- 为了确定诊断为原发性阿尔多斯特隆症 (PA) 的患者中正常张力玻璃眼 (NTG) 的患病率.
- 评估与没有PA的高血压患者相比,在PA患者中NTG的风险.
主要方法:
- 对新诊断的PA患者进行了一项横截面研究.
- 眼科检查包括眼内压力测量,中角膜厚度,裂纹灯生物显微镜,视镜,眼镜镜, fundus摄影,视野测试和光学连贯性断层扫描.
- 青光眼的诊断是基于光盘的外观,周边测量结果,OCT发现和其他眼睛参数.
主要成果:
- 在212名PA患者中,NTG的患病率为11.8%.
- 与没有PA的高血压患者 (5.2%) 相比,PA患者的NTG患病率显著更高 (OR=4.019,P=.022).
- 随着年龄的增长,NTG的患病率从40-49岁的8.8%增加到70岁及以上的37.5%.
结论:
- 主要阿尔多斯特症患者表现出正常张力玻璃眼的显著流行率.
- 血压高与NTG的风险增加有关,这种风险并非由血压介导.
- 这些发现强调了眼科查在PA患者中的重要性.
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