在非运动员马拉松跑者急性运动后,造血干细胞数量的变化
Özgür Günaştı1, Çiğdem Özdemir1, Kerem T Özgünen1
1Department of Physiology, Medical Faculty, Çukurova University, Adana, Turkey.
Advances in medical sciences
|September 16, 2024
概括
以个性化的步伐跑步可显著增加血造干细胞 (HSCs),长达24小时. 这一发现表明,个性化炼可能会增强对潜在捐赠者的HSC动员.
科学领域:
- 运动生理学 运动生理学
- 血液学 血液学 血液学
- 干细胞动员 干细胞动员
背景情况:
- 血造干细胞 (HSC) 移植是血液恶性瘤的治疗选择.
- 颗粒细胞殖民地刺激因子 (G-CSF) 通常用于调动通常稀缺的CD34+细胞.
- 新出现的证据表明,运动可以暂时调动HSC,但最佳的协议仍然不清楚.
研究的目的:
- 为了确定60分钟以个性化强度的跑步是否会显著增加循环中的CD34+ HSC水平.
- 为了调查这次演习引起的HSC动员的持续时间.
主要方法:
- 18名健康的跑步者 (平均年龄为48.2岁) 接受了心肺运动测试,以确定他们的呼吸门 (VT).
- 参与者完成了60分钟的跑步机跑步,其强度接近他们的静脉道.
- 血液样本在运行前,运行后立即收集,并在运行后1,4和24小时收集,以量化CD34+ HSC计数.
主要成果:
- 基线CD34+ HSC水平平均为13.9细胞/μl,在60分钟运行后立即显著增加到19.5细胞/μl (p <0.05).
- 在运动后的1,4小时和24小时,分别观察到15.3个,19.5个和15.1个细胞/μl的水平.
- 个人数据显示,一些参与者在运动前后都超过了HSC的移植限值.
结论:
- 在VT附近的强度下进行60分钟的跑步会有效地调动CD34+ HSCs.
- 观察到的HSCs的增加在运动后至少24小时保持.
- 个性化的运动方案可以作为一个有价值的,非药物战略,以增加周围血液CD34+HSCs的潜在捐赠者.
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