基于机器学习的早期预警系统对患者病情恶化的临床评估
Amol A Verma1, Therese A Stukel2, Michael Colacci2
1St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont. amol.verma@mail.utoronto.ca.
概括
机器学习预警系统 (EWS) 减少了一般内科病房的患者死亡. 这种实时系统有望改善医院的临床结果和患者安全.
科学领域:
- 医疗保健技术 技术 医疗保健 技术
- 临床信息学 临床信息学
- 预测分析是一种预测分析.
背景情况:
- 基于ML的EWS对患者病情恶化的实施和临床影响尚未得到充分描述.
- 研究集中在一个学术医疗中心的一般内科 (GIM) 单位的多方面的,实时的基于ML的EWS上.
研究的目的:
- 描述基于ML的新型EWS的实施和评估.
- 评估ML-EWS与临床结果之间的关联,特别是非息性住院死亡.
主要方法:
- 使用基于倾向分数的重叠权重的非随机对照研究.
- 在干预期间 (2020年11月至2022年6月) 与干预前 (2016年11月至2020年6月) 的GIM单位患者进行了比较.
- 差异分析将GIM与未接受干预的子专业单位 (心脏病学,呼吸学,科) 进行了比较.
主要成果:
- 包括13,649个GIM招生和8,470个子专业招生.
- 在干预期间,非息性死亡减少了GIM (1.6%对2.1%,aRR 0.74).
- 具有警报的高风险GIM患者的死亡率较低 (7.1%与10.3%,aRR为0.69).
结论:
- 在GIM部门实施基于ML的EWS与非息性死亡风险降低有关.
- 基于ML的EWS代表了增强医院环境中临床结果的有希望的技术.
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