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MCF分类器:估计,标准化和分层药物的碳足迹,在规模上

Haroon Taylor¹, Shazia Mahamdallie¹, Matthew Sawyer²

¹YewMaker, London, UK.

British journal of clinical pharmacology

|September 16, 2024

概括

一个新的分类器估计了药物的碳足迹,揭示了常见药物的大量排放. 减少抗生素处方可以大幅减少医疗保健.

科学领域:

环境科学环境科学
制药科学制药科学
公共卫生公共卫生

背景情况:

医疗保健对全球温室气体排放作出了重大贡献.
药物碳足迹的产品级数据有限,阻碍了有效的缓解策略.
制药行业面临着越来越大的压力,需要与净零承诺保持一致.

研究的目的:

开发和实施医学碳足迹 (MCF) 分类器,用于估计,标准化,分层和可视化医学碳足迹.
为制药产品提供可访问的产品级碳足迹数据.
为了确定药物使用中减排的高影响领域.

主要方法:

利用分子重量和化学结构来计算小分子药物的活性制药成分的过程质量强度和全球变暖潜力.
每剂量估计的药物碳足迹和分配的MCF评级.
开发了可搜索的MCF Formulary网络应用程序,以实现数据可访问性.
进行了评级准确性的验证,比较和敏感性分析.
根据治疗指示进行了分层分析.

主要成果:

为2214种药品生成了标准化碳足迹,分别为38%低,35%中等,25%高,2%非常高.
分析的产品占到2023年1月英格兰NHS处方的22亿剂量,总碳足迹为14万CO2e.
三种特定的抗生素 (阿莫西西林,流西林,青素V) 占总排放量的15%.
如果减少20%的抗生素处方,每月可以节省4200二氧化碳.

结论:

标准化医药碳足迹数据对于评估和减轻制药排放非常有价值.
该MCF分类器和表格可以为调整医疗保健实践与净零目标的干预提供信息.
有针对性的降低,特别是在抗生素处方方面,为环境带来了显著的好处.

关键词:

抗生素抗生素是一种抗生素.医学碳足迹医学碳足迹净零医疗保健是什么意思这是一个处方书.药品的高质量使用.可持续的药物可持续的药物

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