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通过24小时的隐形眼镜传感器配置来预测正常张力玻璃眼病患者的玻璃眼病进展情况

Tomomi Higashide¹, Sachiko Udagawa², Kazuki Nakazawa²

¹Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan. eyetomo@med.kanazawa-u.ac.jp.

Scientific reports

|September 16, 2024

概括

隐形眼镜传感器 (CLS) 可以预测正常张力玻璃眼 (NTG) 的进展. 较低的夜间眼脉冲振幅变化和较高的白天眼内压力 (IOP) 范围在基线,加上光盘出血,是关键的危险因素.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
生物医学工程生物医学工程

背景情况:

正常张力玻璃眼 (NTG) 是一种渐进的视神经病变,眼内压力 (IOP) 处于统计学上正常的范围内.
在NTG患者中预测青光眼的进展仍然具有挑战性,需要新的监测工具.
隐形眼镜传感器 (CLS) 提供眼睛生物机械变化的持续24小时监测.

研究的目的:

调查24小时CLS参数对NTG患者绿眼病进展的预测值.
确定特定的CLS衍生指标和与疾病进展相关的临床因素.

主要方法:

一项前性队列研究涉及79名NTG患者,平均监测时间为48.1个月.
进行了基线24小时CLS测量 (眼脉冲振幅) 和戈德曼平面化度测量 (日间IOP).
使用汉弗雷视野和 fundus 摄影 (指导进展分析) 评估了青光眼的进展.

主要成果:

在79名患者中,23名患者 (29.1%) 呈现了青光眼的进展.
进展的显著风险因素包括夜间眼脉冲振幅的较小标准偏差 (HR 0.30/mVeq,P=0.016),在基线时较大的白天IOP范围 (HR 1.23/mmHg,P=0.017),以及光盘出血的存在 (HR 4.37,P=0.001).

结论:

在常规的IOP监测之外,CLS测量提供了宝贵的补充信息,用于评估NTG中的青光眼症进展风险.
特定的CLS参数,结合基线IOP变异性和光盘出血,可以帮助识别高风险NTG患者.

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