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Updated: Jun 13, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

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工程TadA ortolog-derived cytosine基编辑器没有动机偏好和腺活性限制

Guoling Li1, Xue Dong1, Jiamin Luo1

  • 1HuidaGene Therapeutics Co., Ltd., Shanghai, 200131, China.

Nature communications
|September 16, 2024
PubMed
概括

设计的细胞因子基编辑器 (CBEs) 克服了现有的Tada变体的局限性. 一个新的编辑器 (aTdCBE) 通过恢复双肌肉发育不良的表达,显示了杜申氏肌肉发育不良的基因治疗的前景.

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