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在抗卡巴因的Acinetobacter baumannii殖民后感染的危险因素

Maddalena Peghin¹, Filippo Givone², Maria de Martino³

¹Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, Varese, Italy. maddalena.peghin@gmail.com.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

|September 16, 2024

概括

如果患有心血管疾病,COVID-19或被送往ICU的患者感染了耐卡巴尼姆的Acinetobacter baumannii (CRAB),他们面临更高的感染风险. 识别这些风险因素对于及时治疗至关重要.

科学领域:

传染性疾病传染性疾病
临界护理医学临界护理医学
流行病学流行病学

背景情况:

耐卡巴尼姆的巴曼尼菌 (CRAB) 在医疗机构中构成重大威胁.
预测CRAB殖民患者的感染发展对于有效的抗生素策略至关重要.

研究的目的:

确定与住院患者从CRAB殖民到活跃感染的进展相关的风险因素.
为了告知临床决策和改善患者的结果.

主要方法:

从2020年1月到2022年12月,对144名住院成年患者进行了回顾性队列研究.
纳入标准:有记录的CRAB殖民或殖民后的CRAB感染.
统计分析包括单变量和多变量后勤回归来确定风险因素.

主要成果:

在殖民患者中,CRAB感染的发生率为27.8%.
从殖民到感染的平均时间为4天.
CRAB感染的独立风险因素包括心血管疾病 (OR 5.83),COVID-19 (OR 3.72) 和重症监护室 (ICU) 的入院 (OR 8.83).
感染患者的住院死亡率 (55.0%) 与仅殖民患者 (32.7%) 相比较高.

结论:

如果他们有潜在的心血管疾病,并发性COVID-19感染,或被录取到ICU,CRAB殖民的住院患者感染的风险增加.
需要进一步的研究,以确定更多的感染预测因素在CRAB殖民个体.

关键词:

这种细菌是Acinetobacter baumannii.抗卡巴胺的阿辛托巴克特宝曼尼菌.殖民化的殖民化具有多种药物耐药性的药物.

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