非对称的信心区间,样本大小公式和对比测试,以达成协议的内部类相关系数在间级可靠性研究
Abderrahmane Bourredjem1,2,3,4, Hervé Cardot3, Hervé Devilliers1,5
1Inserm CIC1432, Clinical Epidemiology Unit, Dijon, France.
Statistics in medicine
|September 16, 2024
概括
本研究详细介绍了使用类内相关系数 (ICCa) 测定评价者间可靠性的统计方法. 它引入了用于计算样本大小的新公式和用于比较群体之间的可靠性的概率比率测试.
科学领域:
- 统计 统计 统计 统计
- 生物统计学 生物统计学
- 心理测量 心理测量 心理测量
背景情况:
- 评估者之间的可靠性对于研究的一致性至关重要.
- 类内相关系数 (ICCa) 是一个关键指标.
- 现有的ICCa分析和样本大小计算方法存在局限性.
研究的目的:
- 对于高斯数据来导出ICCa的非对称正常性.
- 开发和评估一个新的ICCa.信任区间.
- 提出样本大小计算公式和概率比率测试 (LRT) 来比较组之间的ICCa.
主要方法:
- 对于ANOVA,ML和REML估计,ICCa的异常正常性已被证明.
- 使用模拟来评估推导的置信区间的性能.
- 开发和模拟了样本大小计算公式和概率比测试 (LRT).
主要成果:
- 与现有方法相比,衍生的置信区间在各种样本大小中表现良好.
- 建立了计算所需的受试者和评级人员数量的新公式.
- 概率比率测试 (LRT) 显示出适合用于比较子群体之间的ICCa的特性.
结论:
- 建议的置信区间和样本大小公式适用于中大样本.
- 概率比率测试 (LRT) 是有效的比较患者亚群之间的inter-rater可靠性.
- 开发的工具箱解决了评估者之间的可靠性研究中常见的问题.
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