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精简的选平台导致从Tabernanthe iboga中发现帕奇西芬合成酶

Mohamed O Kamileen1,2, Yoko Nakamura1,3, Katrin Luck1

  • 1Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, D-07745, Jena, Germany.

The New phytologist
|September 17, 2024
PubMed
概括

研究人员确定了来自药用植物Tabernanthe iboga的两个关键细胞染色体P450酶,帕西西芬合成酶 (PS) 和16-基-塔伯索宁合成酶 (T16H). 这些酶对于单二醇化物支架的氧化定制至关重要.

关键词:
尼科蒂亚纳 (Nicotiana benthamiana) 是一种植物.在Tabernanthe iboga的酒馆里.这是一种类化物.细胞染色体P450的使用.帕奇西芬 (Pachysiphine) 是一种可怕的药物.植物的生物合成.植物天然产品植物天然产品

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...