微针作为改善对细菌感染的抗生素输送的潜在平台
Zainab Mohammed Abid Al-Wahaab1, Mohammed Hussain Al-Mayahy1
1Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Heliyon
|September 17, 2024
概括
微针提供了抗生素输送的最小侵入性替代方案,克服了口服生物可用性差和针恐惧症等挑战. 这种方法增强了对细菌感染的药物输送,可能降低了耐药性.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 传统的口服抗生素管理面临限制,包括生物可用性差,胃肠道副作用,以及耐药细菌菌株的增加.
- 患者的针恐惧症和局部抗生素的皮肤透性差,妨碍了有效的治疗,需要使用替代的输送方法.
- 微针 (MNs) 是用于局部或全身药物输送的最小侵入性技术,提供了患者友好的替代方案.
研究的目的:
- 审查微针 (MN) 在抗生素输送中的应用.
- 讨论MNs在治疗细菌感染中的优点和局限性.
- 突出最近在将抗生素纳入MNs用于局部和透皮输送方面的进展.
主要方法:
- 文献综述,重点关注微针技术和抗生素输送.
- 对将抗生素纳入各种MN设计的研究进行分析.
- 对局部和通过皮肤给予抗生素的MN疗效的评估.
主要成果:
- 微针提供一种无痛的,可自给药的抗生素输送方法,绕过了常见的口服途径限制.
- 为了有效的抗生素结合和释放,已经开发和研究了各种MN类型.
- 研究表明,MNs对于细菌感染的局部和全身治疗都有潜力.
结论:
- 微针是推动抗生素输送的有希望的平台,解决与传统方法相关的挑战.
- 进一步研究和开发MN技术可以显著改善细菌感染的管理.
- 该审查强调了微针在提高抗生素疗效和患者服药性方面的潜力.
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