一个由PRDM16驱动的信号调节了用治疗的阴茎男性的身体组成
Siresha Bathina1,2, Georgia Colleluori1, Dennis T Villareal1,2
1Division of Endocrinology Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, United States.
Frontiers in endocrinology
|September 17, 2024
概括
丸激素治疗将分子途径从脂肪生产转移到肌肉发育. 这种由PRDM16和雌激醇调解的变化减少了身体脂肪,增加了瘦肉量.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 人体生理学 人体生理学
背景情况:
- 众所周知, (T) 疗法可以增加肌肉质量,并减少阴茎下男性的脂肪质量.
- 正确的分子机制驱动这些身体组成的相互变化仍然不清楚.
研究的目的:
- 为了研究在接受丸激素治疗的男性下腺体构成变化背后的分子机制.
- 检查基因和蛋白质水平上脂肪生成和肌生成途径的变化.
主要方法:
- 一项临床试验的二次分析,该试验涉及105名接受酸治疗18个月的男性.
- 使用实时定量PCR测量皮下脂肪 (SCF) 和外周血液单核细胞 (PBMC) 中的脂肪原和肌原标记物.
- 通过ELISA对特定蛋白质 (FOLLISTATIN,PAX7,MYOSTATIN,ADIPSIN,PRDM16) 的血清水平进行量化.
主要成果:
- 6个月后,丸激素治疗显著增加了丸激素和雌激素水平,减少了脂肪质量,增加了瘦肉质量.
- 观察到脂肪生成标记物 (PPARγ,ADIPSIN) 的减少和肌质生成标记物 (MYOD,PAX7,FOLLISTATIN) 的增加.
- 显著增加PRDM16表达和蛋白质水平,这表明在脂肪-肌原开关中发挥了作用.
结论:
- 丸激素疗法诱导了一个分子转移从脂肪生成到肌体生成在男性下腺.
- 增强的PRDM16活性,可能由雌激素的增加驱动,调解脂肪质量的减少和脂肪质量的增加.
- 这些发现阐明了在替代疗法中观察到的身体组成变化的分子基础.
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