获得生育的途径:目前对母马子宫内膜炎和子宫内膜异位的治疗方法
Graça Ml Ferreira-Dias1,2, Joana Alpoim-Moreira1,2, Anna Szóstek-Mioduchowska3
1Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal.
Animal reproduction
|September 17, 2024
概括
了解马的生育能力涉及荷尔蒙,免疫,遗传和表观遗传因素. 慢性炎症,如子宫内膜炎,可以导致纤维化并影响生育能力,III型原体 (COL3) 显示出诊断潜力.
科学领域:
- 马类繁殖中的生殖生物学和免疫学.
背景情况:
- 马的生育能力受到复杂的荷尔蒙,免疫,遗传和表观遗传因素的影响.
- 像子宫内膜炎这样的病理会发展为子宫内膜异位症,影响生殖成功.
- 中性细胞外细胞陷 (NETs) 在炎症中发挥作用,可能导致慢性疾病.
研究的目的:
- 探索导致母体内膜纤维化和生育问题的细胞机制.
- 研究炎症,矩阵金属蛋白酶和子宫内膜异位症的表观遗传变化的作用.
- 确定潜在的诊断生物标志物和治疗目标,以改善马的生育能力.
主要方法:
- 关于马匹生殖生理学和病理学的当前文献的综述.
- 分析中性粒细胞,NETosis,矩阵金属蛋白酶和表观遗传修饰的作用.
- 评估III型原体 (COL3) 作为子宫内膜异位症的潜在生物标志物.
主要成果:
- 长期的炎症,特别是子宫内膜炎,可能导致慢性子宫内膜炎,子宫内膜异位症和生育能力下降.
- 矩阵金属蛋白酶和表观遗传变化是子宫内膜异位症进展的关键因素.
- 第三种类型的原体 (COL3) 作为评估子宫内膜异位症和生育能力的非侵入性生物标志物具有前景.
结论:
- 了解母马子宫内膜纤维化细胞机制对于生育管理至关重要.
- 表观遗传修饰和特定的酶抑制剂提供了潜在的治疗途径.
- 第三种类型的原体 (COL3) 可以作为一种有价值的诊断工具,补充传统方法.
相关概念视频
Fertilization
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
Uterine Tubes
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...


