长期的冠状病毒疾病2019年后,仿真抗原受体-T细胞疗法成功治疗了连续的多药疗法
Masahiro Yamashita1, Hisao Higo1, Nobuharu Fujii2
1Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.
Respiratory medicine case reports
|September 17, 2024
概括
一名用仿真抗原受体-T细胞治疗的淋巴瘤患者患有严重的COVID-19. 多种抗病毒治疗有助于管理她长期的COVID-19症状和肺部异常.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 化学抗原受体-T细胞 (CAR-T) 疗法是一种新的血液恶性瘤治疗方法.
- 接受CAR-T治疗的患者可能免疫受损,增加对COVID-19等严重感染的易感性.
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
研究的目的:
- 为了调查一种长期COVID-19病例,该病例是在仿真抗原受体T细胞治疗后发生的.
- 为了分析涉及的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 的基因组变异.
- 评估长期COVID-19治疗各种治疗干预措施的疗效.
主要方法:
- 基因组分析以确定SARS-CoV-2变种 (奥米克朗BA.1.1.2).
- 诊断成像 (CT扫描) 以评估肺部参与 (地面玻璃不透明).
- 使用多种抗病毒药物,包括remdesivir,molnupiravir,nirmatrelvir/ritonavir和 tixagevimab/cilgavimab.
主要成果:
- 该患者被诊断患有长期的COVID-19,尽管接受了皮质类固醇治疗,但其特点是持续的地面玻璃不透明.
- 确定的SARS-CoV-2变种是奥米克朗BA.1.1.2.2.
- 抗病毒疗法的组合似乎有助于长期COVID-19的临床改善.
结论:
- 长期的COVID-19可能发生在免疫功能低下的患者中,即使在初始治疗后.
- 多种抗病毒药物可能是必要的,以管理复杂的长期COVID-19病例.
- 这一案例强调了在接受高级癌症治疗的患者中对COVID-19进行警监测和量身定制的治疗策略的重要性.
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