在癌症患者中,尽管有健康益处,但增强剂的摄入量较低
Jane C Figueiredo1,2, Julia Levy1, So Yung Choi3
1Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
iScience
|September 17, 2024
概括
癌症患者需要COVID-19助推剂以获得更好的免疫力. 重复增强剂改善了抗体和T细胞反应,并降低了这一高风险组的死亡风险.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 癌症患者面临更高的COVID-19死亡风险.
- 他们对SARS-CoV-2疫苗的免疫反应减弱.
- 这就需要优化疫苗接种策略,包括定期接种疫苗.
研究的目的:
- 评估在接受活性治疗的癌症患者中,COVID-19增剂疫苗的接种率和有效性.
- 评估助推剂对这种脆弱人群免疫反应和死亡率的影响.
主要方法:
- 综合的图表审查和患者调查.
- 对SARS-CoV-2抗体的血清学评估.
- 用于细胞免疫分析的T细胞受体 (TCR) β测序.
- 对982名癌症患者队列的分析 (2020年11月 - 2023年3月).
主要成果:
- 92.3%的人接种了初级疫苗,70.8%的人接种了单价增剂,但只有30.1%的人接种了双价增剂.
- 在50岁以下的患者和非洲裔美国人或西班牙裔个人中,增强剂的吸收率较低.
- 超过99%的血清转化在2个以上的增强剂后,细胞反应得到改善.
- 接收增剂与所有原因死亡率降低39%的风险相关 (HR=0.61,p=0.024).
结论:
- 重复的COVID-19助推剂可以增强癌症患者的免疫反应.
- 在这个高风险群体中,增强剂的吸收仍然不够理想,特别是在某些人口统计学群体中.
- 提高癌症患者复发疫苗接种率的策略至关重要.
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