在患有孤立REM睡眠行为障碍的患者中,使用便秘评估尺度的肠道运动频率和难以排便
Tomoyuki Miyamoto1, Itsuo Nakajima2, Takuo Arikawa2
1Department of Neurology, Dokkyo Medical University Saitama Medical Center, Japan.
Clinical parkinsonism & related disorders
|September 17, 2024
概括
便秘常见于孤立的快速眼动睡眠行为障碍 (IRBD),这是帕金森病的前体.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
背景情况:
- 孤立的快速眼动睡眠行为障碍 (IRBD) 是神经退行性疾病的前兆阶段,如帕金森病 (PD) 和具有勒维体 (DLB) 的痴呆症.
- 便秘是前兆性和已确定的同核蛋白病变中经常报告的非运动性症状.
研究的目的:
- 评估IRBD患者便秘的患病率和严重程度.
- 调查通过便秘评估量表 (CAS-J) 评估的便秘是否可以预测转化为PD或DLB的现象.
主要方法:
- 一组151名视频多睡眠学确认的IRBD患者和22名对照患者使用日本版本的便秘评估量表 (CAS-J) 进行了评估.
- 进行了纵向后续评估,以监测现象转化到PD或DLB.
- 为了确定CAS-J分数的预测值,使用了统计分析,包括日志级别测试和Cox危险分析.
主要成果:
- 与对照组相比,IRBD患者的CAS-J分数显著更高.
- 患有IRBD的女性报告说,比男性更严重的便秘.
- 较高的CAS-J评分 (≥2) 与显著缩短到PD或DLB (p < 0.001) 变现的时间有关.
- 考克斯危害分析证实,CAS-J评分是转换的重要预测指标 (HR:5.9,p = 0.003).
结论:
- 便秘是中年和老年人患有IRBD的一个普遍问题.
- 在IRBD患者中,CAS-J得分作为一种有价值的预测标志物,用于对帕金森病或勒维体痴呆症的表转化.
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