在门诊化疗单位接受治疗的COVID-19患者
Shiori Kinoshita1,2, Masashi Takemoto3, Minami Asaoka1,3
1Department of Clinical Oncology, Nagoya City University, Nagoya, Japan.
Japanese journal of clinical oncology
|September 17, 2024
概括
接受化疗并感染COVID-19的患者在重新开始治疗之前可能需要延长恢复时间. 多发性骨髓瘤患者通常比固体瘤患者更长时间保持SARS-CoV-2阳性,需要仔细监测.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 随着COVID-19大流行,癌症护理受到干扰,因此感染病人的化疗中断是必要的.
- 在SARS-CoV-2感染后安全恢复化疗方面缺乏明确的指导方针.
研究的目的:
- 确定在COVID-19感染后恢复门诊化疗的安全时间.
- 为了比较血液和固体瘤患者之间的SARS-CoV-2抗原阳性持续时间.
主要方法:
- 对40名因COVID-19而需要中断化疗的患者进行了回顾性研究.
- 在感染后的不同时间点对SARS-CoV-2抗原状态的分析.
主要成果:
- 在40名患者中,有34名患者成功地重新开始化疗.
- 六名患者 (四名患有多发性骨髓瘤,一名患有毛囊性淋巴瘤,一名患有质瘤) 在发病20天后检测出SARS-CoV-2抗原呈阳性.
- 与固体瘤患者相比,多发性骨髓瘤患者的抗原阳性持续时间 (>20天) 显著更高.
结论:
- 大多数固体瘤患者在20天内清除SARS-CoV-2抗原.
- 多发性骨髓瘤患者可能需要在恢复化疗之前进行序列抗原测试,因为长时间的阳性反应.
- 个体化评估对于在COVID-19后免疫功能低下的患者重新开始化疗至关重要.
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