测试早期逆境,神经功能和精神病理学的概念模型:回顾性观察队列研究的协议
Nicolas Murgueitio1, Maresa Tate1, Lucy Lurie1
1Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
JMIR research protocols
|September 17, 2024
概括
这项研究调查了早期生活中的逆境,如剥夺和威胁,如何通过神经生物学途径影响儿童精神病理. 这些发现将揭示在关键发育时期早期逆境的生物嵌入.
科学领域:
- 发展心理学是发展心理学.
- 神经科学是一个神经科学.
- 儿童精神病理学 儿童精神病理学
背景情况:
- 早期的逆境是常见的,并增加了精神病理学的风险.
- 与认知缺陷相关的剥夺;恐惧学习和情绪失调的威胁.
- 大多数研究对较旧的样本进行,缺乏发育可塑性的峰值.
研究的目的:
- 检查早期儿童 (4-7岁) 剥夺,威胁和不可预测性的神经生物学和行为机制.
- 在发育可塑性峰值之后,调查心理病理的风险.
- 描述研究的理由,目标,设计,程序和分析计划.
主要方法:
- 追溯性队列研究检查剥夺,威胁和神经生物学机制.
- 301名儿童 (4-7岁) 和家庭的便利样本.
- 通过家庭和实验室访问收集数据,包括神经成像;分析包括回归和fMRI.
主要成果:
- 参与者招募 (N=301) 完成;数据收集正在进行中.
- 预计结果将于2024年公布.
- 功能性磁共振成像将探索神经功能的作用.
结论:
- 这些发现将阐明神经生物学机制,将早期逆境与儿童精神病理联系起来.
- 代表了早期逆境的生物嵌入理论的最早测试.
- 提供了对风险的发育途径的关键见解.
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