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协生菌对生死性肠球炎和非常低出生体重婴儿的全肠食的影响:双盲随机对照试验

Amir Ali Mahboobipour¹, Ali Bitaraf², Pourang Mohammadi²

¹Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

|September 17, 2024

概括

多菌株共生药物显著降低了出生时体重非常低 (VLBW) 婴儿中死性肠球炎 (NEC) 的发生率. 这种干预措施还改善了食耐受性和体重增加,为VLBW新生儿提供了一个有希望的策略.

科学领域:

新生儿医学新生儿医学
微生物组研究微生物组研究
胃肠病学胃肠病学

背景情况:

死性肠球炎 (NEC) 是一种严重的疾病,影响过早出生的婴儿,与异常的肠道细菌有关.
协生菌,结合益生菌和益生菌,可以调节肠道微生物群.

研究的目的:

评估一种特定的多菌株协生菌 (PediLact®) 在预防非常低出生体重 (VLBW) 新生儿中NEC的疗效.
评估协生菌对营养参数和脆弱群体的食耐受性的影响.

主要方法:

一个双盲,随机对照试验,涉及118名VLBW新生儿.
婴儿接受多菌株共生药或安慰剂,直到完全食.
统计分析包括逻辑双项回归和ANOVA/ANCOVA模型.

主要成果:

协生菌的使用显著降低了NEC发病率 (调整RR=0.22) 和食不耐受 (调整RR=0.27).
接受共生菌的婴儿体重增加有所改善 (SMD=0.63) 并且完全肠道养的时间更短.
住院时间也减少了大约3天,没有报告严重的副作用.

结论:

多菌株协生菌在降低VLBW婴儿中NEC发病率方面是有效的.
协生菌对新生儿的食耐受性和体重增加速度产生有益影响.
医生可能会考虑将共生菌作为VLBW新生儿的治疗选择.

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