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Updated: Jun 12, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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CYP3A4和CYP3A5多形态和基因型组合的分布与塔克罗利斯代谢有关

Ibtissem Hannachi1, Zohra Chadli1, Emna Kerkeni2

  • 1Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.

La Tunisie medicale
|September 17, 2024
PubMed
概括

在CYP3A4和CYP3A5中的遗传变异会影响塔克罗利的代谢. 这项研究对突尼斯人的CYP3A4*1B,CYP3A4*22和CYP3A5*3多态性进行了表征,显示中间代谢器占主导地位.

关键词:
在 CYP3A4*1B 中.由于CYP3A4*22的存在,在 CYP3A5*3*3 中.药物遗传学 药物遗传学突尼斯人口突尼斯人口这就是塔克罗利斯.

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