在临床实践中治疗性结肠炎的乌斯特基努马布的长期益处:ULISES研究
María Chaparro1, Sandra Hermida1, Diana Acosta1
1Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
乌斯特基努马布在性结肠炎 (UC) 患者中表现出良好的耐用性和有效性,即使是那些患有耐火性疾病的患者. 安全性概况与之前的研究保持一致,表明有利的治疗选择.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乌斯特基努马布是一种已批准的治疗性结肠炎 (UC) 的生物疗法.
- 关于乌斯特基努马布在UC的长期有效性和耐久性的现实数据至关重要.
研究的目的:
- 评估ustekinumab在现实世界UC患者队列中的耐用性和短期有效性.
- 在临床实践中评估乌斯特基努马布的耐受性和安全性.
主要方法:
- 追溯性多中心研究,涉及620名性结肠炎患者.
- 患者至少接受了16周的乌斯特基努马布治疗;随访直到停药或最后一次诊所访问.
- 分析了在基线时患有活跃疾病的患者的疗效;缓解是由缺乏类固醇来定义的.
主要成果:
- 在中位数为12个月的随访期间,在25%的患者中发生了乌斯特基努马布的中止 (20%每病人的年份).
- 基线贫血,类固醇使用和严重疾病活动增加了停止治疗的风险.
- 在16周,40%的患者实现了无类固醇缓解;中度至重度的疾病,男性性别和先前的生物药物降低了缓解的可能性.
- 28%的患者出现了不良事件;对肠外表现没有负面影响.
结论:
- 乌斯特基努马布在性结肠炎中表现出相对较高的耐用性和有效性,包括耐火病例.
- 在临床实践中ustekinumab的安全性概况与之前的研究结果一致.
- 乌斯特基努马布代表了性结肠炎患者的可行的治疗选择.
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