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从微丸精子提取取出的精子的比较运动性评估:一个单中心研究比较新鲜和冷解的精子

Raneen Sawaid Kaiyal¹, Darren J Bryk¹, Shinnosuke Kuroda¹

¹Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

The Australian & New Zealand journal of obstetrics & gynaecology

|September 17, 2024

概括

与冷样本相比,新鲜的微手术丸精子提取 (microTESE) 为细胞内质精子注射 (ICSI) 提供了优越的精子运动性. 这一发现有助于为接受ICSI的非阻塞性亚精子症 (NOA) 患者选择最佳的精子检索方法.

科学领域:

生殖医学生殖医学
安德罗学与人类学
不孕症治疗不孕症治疗

背景情况:

微手术丸精子提取 (microTESE) 是非阻塞性精子缺血症 (NOA) 的关键治疗方法.
它提供了使用新鲜或冷精子用于细胞体内精子注射 (ICSI) 的选择.
精子运动性是成功进行ICSI的关键因素.

研究的目的:

为了比较新鲜微型TESE与冷微型TESE对ICSI精子可用性的影响.
评估精子冷保存对运动性的影响.
为NOA患者的患者选择和咨询提供信息.

主要方法:

在113名NOA患者中对128个微TESE手术 (2007-2021) 的回顾性分析.
患者分为新鲜 (FR组) 和冷 (FZ组) 的微TESE组.
对ICSI进行精子回收率和解后运动率的比较.

主要成果:

在新鲜的微型TESE (67.7%) 与冷的 (45.3%) 相比,精子提取率更高.
新鲜样本显示85.7%的精子是ICSI的运动精子.
冷样本的初始运动率为81.8%,在解后降至52.7%.

结论:

与新鲜相比,冷的微TESE显著降低了ICSI的运动精子可用性.
新鲜的microTESE可以为接受ICSI的夫妇提供优势,尽管存在后勤方面的考虑.
仔细的患者选择和咨询对于优化NOA治疗结果至关重要.

关键词:

美国国务院调查局 (ICSI)在体外受精 in vitro受精男性因子不孕不育的原因非阻塞性阿佐精子症.精子的运动性精子的运动性

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