探索人类肠道微生物群的维生素生物合成景观
Chiara Tarracchini1, Gabriele Andrea Lugli1,2, Leonardo Mancabelli2,3
1Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
mSystems
|September 17, 2024
概括
人的肠道微生物组可以产生必需的维生素B和维生素K.这项研究分析了8,000个微生物组,揭示了年龄和起源如何影响维生素合成途径,并确定了关键的微生物.
科学领域:
- 微生物组研究的研究.
- 营养生物化学 营养生物化学
- 人类健康 人类健康 人类健康
背景情况:
- 人的肠道微生物群合成必需的维生素,特别是维生素B,对宿主和微生物生物过程至关重要.
- 目前关于微生物维生素合成的知识依赖于有限的基因组和单一培养研究,缺乏对复杂社区潜力的全面了解.
研究的目的:
- 评估大约8000个人类肠道微生物组的维生素 (B组和K组) 生合成潜力.
- 研究宿主相关因素对微生物维生素合成途径的影响.
- 为了确定关键的肠道微生物物种,在人类一生中为维生素生物合成作出贡献.
主要方法:
- 利用了涉及B组和K维生素生物合成的综合基因组 (>100个基因).
- 分析了约8,000个人类肠道微生物组数据集的维生素生物合成潜力.
- 采用微生物协会网络分析来推断功能角色.
主要成果:
- 宿主因素,如年龄和地理来源,显著影响维生素生物合成途径的多样性和丰富性.
- 特定的肠道微生物群成员被确定为不同的人类生命阶段对维生素合成的主要贡献者.
- 发现叶酸和可巴胺酸在婴儿和成人肠道微生物社区平衡中分别起着关键作用.
结论:
- 这项研究提供了对人类肠道中微生物介导的维生素生物合成的广泛理解.
- 这些发现突出了通过调节肠道微生物群来改善必需微量营养素可用性的潜在目标.
- 确定了关键的微生物参与者及其在复杂的肠道生态系统内维生素生产中的作用.
相关概念视频
Bacterial Flora of the Large Intestine
397
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
397
Anatomy of the Intestines
71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K
The Roles of Bacteria and Fungi in Plant Nutrition
35.1K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
35.1K
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K


