相关实验视频

Updated: Jun 12, 2025

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

来自巴西的Campylobacter jejuni和Campylobacter coli多药耐药菌株的基因组草案,代表了新的序列类型

Ana Beatriz Portes^1,2, Pedro Panzenhagen^1,3, Anamaria Mota Pereira Dos Santos^1,2

¹Laboratory of Advanced Analysis in Biochemistry and Molecular Biology, Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Microbiology resource announcements

|September 17, 2024

概括

全基因组测序揭示了具有抗微生物耐药性的新型坎皮洛巴克特菌株 (ST-12332,ST-12333,ST-12663). 这些发现强调了对动物和人类种群中耐药细菌的预防策略的必要性.

科学领域:

微生物学微生物学
基因组学就是基因组学.
抗微生物耐药性抗微生物耐药性

背景情况:

在全球范围内,Campylobacter 菌种是导致细菌性胃肠炎的首要原因.
坎皮洛巴克的抗菌素耐药性构成了严重的公共卫生威胁.
关于新型序列类型及其电阻概况的知识有限.

研究的目的:

为了识别和表征Campylobacter的新型多部位序列类型 (MLST).
为了确定这些新型菌株的抗微生物耐药性基因载体.
为了研究耐药性Campylobacter循环的One Health影响.

主要方法:

全基因组测序 (WGS) 用于进行综合遗传分析.
使用WGS数据进行了MLST类型化.
通过生物信息学分析确定了抗菌素耐药性基因.

主要成果:

确定了三个新的MLSTs:Campylobacter jejuniST-12332,大肠杆菌ST-12333和大肠杆菌ST-12663.
这些新型菌株含有耐药性基因,使其对多种抗菌类药物产生耐药性.
隔离来源表明,这些耐药菌株在动物水库和人类感染中存在.

结论:

发现了新的,多药耐药的Campylobacter菌株,需要加强监测.
了解动物和人类之间的传播动态对于控制至关重要.
实施预防措施对于缓解抗菌素耐药性传播至关重要.

关键词:

这是坎比洛巴克特菌.抗生素耐药性抗生素耐药性抗微生物耐药性抗微生物耐药性基因组学就是基因组学.多个位置的序列类型化

更多相关视频

Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP

Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP

Published on: October 30, 2016

Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products

Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products

Published on: February 23, 2024

相关概念视频

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

Genome Size and the Evolution of New Genes

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.