侧面皮质脊柱体通道标志:一个MRI标记物用于肌缩侧面硬化症
Maria Janina Wendebourg1, Eva Kesenheimer1, Laura Sander1
1From the Translational Imaging in Neurology (ThINk), Department of Biomedical Engineering (M.J.W., E.K., L.S., M. Weigel, C.G., R.S.), Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (M.J.W., E.K., L.S., M. Weigel, C.G., R.S.), Department of Biomedical Engineering (M. Weigel, C.W., O.B.), Institute of Forensic Medicine, Department of Biomedical Engineering (D.N., E.S., C.L.), and Department of Biomedicine (M.S.), University of Basel, Basel, Switzerland; Neurology Clinic and Policlinic, Department of Clinical Research (E.K., L.S., M. Weigel, M.D., N.N., C.G., K.S., M.S., R.S.), Division of Radiological Physics, Department of Radiology (M. Weigel, C.W., T.H., P.M., O.B.), Department of Pathology, Institute of Medical Genetics and Pathology (N.D.), and Department of Theragnostics, Clinic of Radiology and Nuclear Medicine, Division of Diagnostic and Interventional Neuroradiology (J.L.), and Department of Neurology (R.S.), University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland; Institute of Neuropathology, Neurocenter, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany (M.D.); Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland (D.N., E.S., C.L.); and Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St Gallen, St Gallen, Switzerland (C.N., N.B., M. Weber).
放射性采样的平均磁化反转恢复 (rAMIRA) MRI显示在侧面皮质脊柱管 (CST) 中呈现高强度信号,可以准确检测肌缩侧面硬化症 (ALS). 这种成像标志物显示出高灵敏度和特异性,用于识别ALS患者上部运动神经元退化.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 放射性采样的平均磁化逆转恢复采集 (rAMIRA) 图像显示,在运动神经元疾病患者的侧面皮质脊髓管 (CST) 中出现过强度.
- 这一发现表明,对影响中枢神经系统的神经退行性疾病的潜在成像生物标志物.
研究的目的:
- 系统地评估横向CST标志的诊断准确性,使用rAMIRAMRI检测肌缩性横向硬化症 (ALS).
主要方法:
- 分析了ALS和其他运动神经元疾病研究的前性数据.
- 参与者在四个宫水平进行了3-T轴向2D rAMIRA成像.
- 侧面的CST信号被定义为脊髓白质高强度的背侧到前角,超过背脊柱信号强度.
- 在研究数据集和独立验证数据集中评估了准确性.
- 在一个参与者身上进行了死后成像和组织病理学.
主要成果:
- 该研究包括患有ALS,脊髓灰质炎后综合征,脊髓肌缩以及健康对照患者.
- 在研究数据集中,rAMIRA对ALS显示了60%的敏感性和97%的特异性.
- 在验证数据集中,灵敏度为100%,特异性为93%.
- 组织病理学证实了与rAMIRA高强度相对应的轴突损失.
结论:
- 通过rAMIRA MRI识别的侧向CST标志是检测ALS上部运动神经元退化的一个有希望的标志物.
- 这种成像技术可能有助于诊断和评估ALS.
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