一个患有眼科移植对宿主疾病的患者的初级结合膜菌传染性
Asmaa A Zidan1, Aaron R Kaufman, Anna M Stagner
1Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA.
Cornea
|September 17, 2024
概括
双边结膜性软体感染 (MC) 发生在患有眼部移植对宿主病 (oGVHD) 的免疫受损患者身上. 手术切除消除了MC病变,强调了在oGVHD患者中考虑MC的重要性.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 主要结膜性软体传染性 (MC) 是罕见的,通常在免疫受损的个体中见到.
- 眼部移植对主体疾病 (oGVHD) 可以使患者易患不寻常的感染和病变.
研究的目的:
- 在患有oGVHD的患者中报告罕见的双边初级结膜MC病例.
- 评估在免疫功能低下患者中结膜性MC的诊断方法.
主要方法:
- 一个38岁的女性患有oGVHD的病例报告.
- 临床检查,体内共聚焦显微镜,以及用于诊断的组织病理学.
- 手术切除以去除病变. 手术切除以去除病变.
主要成果:
- 这位患者出现了与MC一致的双边结膜结节性病变.
- 在体内共聚焦显微镜显示了具有包容性的特征性上皮细胞巢.
- 组织病理学证实了MC,手术切除导致了完全的分离和改善了眼睛的舒适性.
结论:
- 在患有oGVHD或其他形式的免疫功能受损的患者的结膜病变的差异诊断中,应考虑结膜MC.
- 在体内共聚焦显微镜是诊断结膜MC的一个有价值的工具.
- 当局部抗病毒疗法不适时,手术切除是结膜性MC的有效治疗方法.
相关概念视频
Microbiome of the Eye
67
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
67
Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102


