如何检测影响识别变化在肌缩性侧面硬化症
Veronica Castelnovo1,2, Elisa Canu1,2, Edoardo Nicolò Aiello3
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Journal of neurology
|September 17, 2024
概括
综合性影响测试系统 (CATS-A) 准确地测量了缩性侧面硬化症 (ALS) 患者的影响识别 (AR). 在ALS中影响识别缺陷可能表明前时间大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 影响识别 (AR) 对社会互动至关重要.
- 肌缩侧面硬化症 (ALS) 可以影响认知功能,包括AR.
- 在ALS中AR评估的临床实用性需要进一步验证.
研究的目的:
- 评估意大利ALS患者AR评估的综合性影响测试系统-简称 (CATS-A) 的临床可用性.
- 为了确定CATS-A AR测量的有效性和诊断准确性.
- 探索AR缺陷和ALS中前时大脑参与之间的关系.
主要方法:
- 96名ALS患者和116名对照患者完成了CATS-A AR子测试.
- 评估了CATS-A AR测量的因数,收和分歧有效性.
- 接收器运行特征分析确定了诊断准确性和AR测量最佳截止值.
主要成果:
- CATS-A AR子测试和AR比率 (ARQ) 显示出中度至强度的有效性.
- 在CATSA AR测量中,可接受的诊断准确度 (AUC范围为0.79-.83).
- 患有ARQ受损的ALS患者在特定的额头和部区域显示灰质体积减少.
结论:
- CATS-A AR子测试,特别是ARQ,对于评估ALS中的AR是可靠的.
- 通过CATS-A识别的AR缺陷可能作为ALS中前功能障碍的标志物.
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