癌症相关腹对癌症治疗变化的影响
Abdullah Aleem1, Maya Charuni Sarihan2, Pablo C Okhuysen3
1Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. abdullah.aleem@uth.tmc.edu.
概括
与癌症相关的腹 (CRD) 显著扰乱了癌症治疗,导致更高的断药率和更低的坚持. 有效的CRD管理对于优化患者治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 与癌症相关的腹 (CRD) 是癌症治疗的常见副作用.
- 对于CRD对癌症治疗参数的影响尚不清楚.
研究的目的:
- 评估CRD对癌症治疗中止,持续,增加,剂量定位和坚持的影响.
主要方法:
- 一项使用IQVIA PharMetrics Plus索赔数据的纵向观察研究.
- 分析了104,135对成年患有CRD和没有CRD的患者的匹配对.
- 使用多变量Cox比例危险模型来评估治疗参数差异.
主要成果:
- 患有CRD的患者在化学疗法,向疗法和组合疗法中治疗中断率显着更高.
- CRD与更高的断药风险相关 (HR=1.40).
- 患有CRD的患者表现出更低的中位时间到停药,切换,持久性和坚持.
结论:
- CRD导致癌症治疗的显著和临床影响的变化,包括停止治疗和切换治疗.
- 在患有CRD的患者中观察到较低的坚持和持久性.
- 迫切需要管理CRD的策略,以优化抗癌治疗.
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