1型糖尿病患者的集中重塑和与代谢相关的脂肪性肝病:一项探索性研究
Klaudia Czarnik1, Zbigniew Sablik2, Anna Borkowska3
1Department of Internal Diseases and Diabetology, Medical University of Lodz, Central Teaching Hospital in Lodz, 251 Pomorska Street, 92-213, Lodz, Poland. klaudia.czarnik@umed.lodz.pl.
Acta diabetologica
|September 17, 2024
概括
在1型糖尿病 (T1D) 的年轻患者中,较高的脂肪肝指数 (FLI) 与左心室 (LV) 改造的风险增加有关. 这表明FLI可能有助于识别需要更密切的心脏监测的T1D患者.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 在1型糖尿病 (T1D) 中,糖尿病性心肌病常常呈现为无症状的透功能障碍和左心室 (LV) 改造.
- 与代谢相关的脂肪性肝病 (MASLD) 在T1D相关的心脏重塑中的作用尚未研究.
- 这项研究调查了MASLD风险和年轻的T1D患者没有心力衰竭的LV重塑之间的联系.
研究的目的:
- 确定通过脂肪肝指数 (FLI) 评估的MASLD风险与年轻T1D患者的相对壁厚 (RWT) 之间的相关性.
- 在T1D中探索FLI和LV重塑指标之间的关联.
- 确定T1D中心脏重塑的潜在预测因素.
主要方法:
- 从住院糖尿病科招募T1D患者.
- 收集实验室测试结果和心声回声数据.
- 使用FLI估计MASLD风险,并对获得的数据进行统计分析.
主要成果:
- 这项研究包括55名T1D患者;25名表现出LV重塑 (RWT>0.42).
- 经过LV重塑的患者的FLI (40.97比13.82) 和BMI (27.3比22.5) 显着更高.
- FLI与LV重塑风险 (OR 1.028,p=0.05) 有相关性,RWT>0.42.4的最佳预测FLI截止值为26.38,RWT>0.42.
结论:
- 脂肪肝指数 (FLI) 与T1D患者的相对壁厚度 (RWT) 有关.
- 这种关联独立于糖尿病代谢控制.
- FLI可以作为一种有价值的工具来识别T1D患者的左心室重塑的高风险.
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