肥胖和治疗目标中的内皮质功能障碍
Atilla Engin1,2
1Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey. dr.aengin@gmail.com.
Advances in experimental medicine and biology
|September 17, 2024
概括
与肥胖相关的炎症和内皮功能障碍加剧了心血管疾病和2型糖尿病. 针对GLP-1激动剂等途径的新型疗法对血管修复和降低代谢风险充满希望.
科学领域:
- 心血管科学 心血管科学
- 代谢性疾病研究研究
- 内分泌学 在内分泌学.
背景情况:
- 全球肥胖率的上升与心血管疾病死亡率的增加有关.
- 肥胖引起的慢性炎症和失调的阿迪波基因会损害血管平衡,导致内皮功能障碍.
- 关键因素包括脂肪组织炎症,氧化 (NO) 生物可用性降低,胰岛素抵抗 (IR) 和氧化低密度脂蛋白 (oxLDLs).
研究的目的:
- 探索与肥胖相关的内皮功能障碍的机制.
- 在肥胖个体中确定心血管保护的治疗点.
- 评估新型药理干预措施的疗效.
主要方法:
- 在肥胖中对周围血管脂肪组织 (PVAT) 变化的分析.
- 研究脂肪细胞-外体细胞-巨细胞交叉的研究.
- 评估临床标记物,如勒素,虹膜素和残留胆固醇.
- 对治疗剂的评估,包括利拉格卢提德,恩帕格利弗洛辛和美特福林.
主要成果:
- 肥胖会改变PVAT,促进炎症,氧化应激,以及亲动脉原性巨细胞表型.
- 利拉格卢提德通过cAMP-独立的PKA-AMPK通路在PVAT中改善血管功能.
- 恩帕格利弗洛辛 (EMPA) 和甲胺可以缓解内皮功能障碍和氧化应激,但缺乏全面的抗炎作用.
- GLP-1受体激动剂和减肥手术显示出血管修复和心脏代谢风险改善的潜力.
结论:
- 肥胖驱动的内皮功能障碍是心代谢综合征和2型糖尿病进展的关键因素.
- 针对特定的途径,如阿尔金酶活性或GLP-1激动性,提供治疗潜力.
- 目前针对肥胖相关糖尿病的治疗方法在同时解决炎症和内皮功能障碍方面存在局限性.
关键词:
非对称的二甲基-l-氨酸 (ADMA)循环氨酸单酸盐 (cGMP) 是一种内皮氧化合成酶 (eNOS) 的作用内皮氧化合成酶 (eNOS) 解离合末端蛋白-1 (ET-1) 是一种脑内皮质 (Endothelium) 是一个内皮质.可以诱导的氧化合成酶 (iNOS)细胞间粘附分子-1 (ICAM-1) 是一种细胞间粘附分子.含有白丰富的重复 (LRR) 和皮林域的蛋白3 (NLRP3) 炎症酶体炎症组.低密度脂蛋白 (LDL) 是一种低密度脂蛋白.氧化 (NO) 是一种氧化.核因子卡帕-B (NF-κB) 的核因子核酸结合和寡合化领域 (NOD)肥胖问题 肥胖问题氧化低密度脂蛋白 (OxLDL) 是一种氧化低密度脂蛋白.过氧化酸盐的过氧酸盐塑原激活剂抑制剂-1 (PAI-1) 是一种蛋白激酶C (PKC) 是一种蛋白激酶.反应性氧物种 (ROS) 是一种反应性氧物种.和脂肪酸是一种和脂肪酸.超氧化物脱酶 (SOD) 是一种超氧化物.瘤亡因子-阿尔法 (TNF-α)血管细胞粘附分子-1 (VCAM-1) 是一种血管内皮生长因子 (VEGF)血管扩张刺激的光蛋白 (VASP)更多相关视频
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