对于益生菌和肠道透性之间的直接联系的有限支持 - - 一项系统性审查
Binayak Acharya1, Marthe Tofthagen1, Marissa L Maciej-Hulme1
1Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, St. Olavs Plass, P.O. Box 4, N-0130, Oslo, Norway.
Glycoconjugate journal
|September 17, 2024
概括
益生菌可以改善肠道透性 (IP),这种情况与各种疾病有关. 然而,目前的研究是有限的,只有一个研究显示出显著的影响,强调需要更多的人体试验.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道屏障对健康至关重要,在炎症性肠病 (IBD) 和病 (CD) 等疾病中可能会受到损害.
- 增加的肠透性 (IP) 允许有害物质转移到体内.
- 饮食中的益生菌,它滋养有益的肠道细菌,正在被探索作为一种增强肠道屏障功能的方法.
研究的目的:
- 系统地审查现有的人类研究,研究益生菌干预对肠道通透性的影响.
- 评估目前的证据,将益生菌使用与改善肠道屏障功能的联系.
主要方法:
- 使用PubMed和Trip数据库对2010年至2023年间发表的研究进行了系统的文献搜索.
- 确定了六项研究,显示出人口特征,研究设计和 prebiotika 干预措施的异质性.
- 用各种生物标志物评估肠道透性,包括乳糖/曼尼托尔,51Cr-EDTA,乳糖/拉姆诺斯,苏克拉洛斯/红,佐努林和类似葡萄糖的2.
主要成果:
- 在六项审查的研究中,只有一个表明了益生菌对肠道通透性的统计学上显著的积极影响.
- 一项研究报告说,在益生菌干预后,肠道微生物组组成在统计上显著改善.
- 在一项研究中观察到松林水平的降低,这表明潜在的障碍改善.
结论:
- 显著缺乏强大的人类研究,调查益生菌对肠道透性的影响.
- 进一步的大规模,标准化的研究是必不可少的,最终确定益生菌干预措施的有效性,以改善肠道屏障功能和解决IP.
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