内脏和肝脏脂肪与心脏结构和功能之间的关联:英国生物库研究
Zhi Lv1, Yangzhi Fu2, Yao Ma1
1Department of Cardiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
The Journal of clinical endocrinology and metabolism
|September 17, 2024
概括
内脏脂肪组织 (VAT) 和肝脂肪 (PDFF) 独立地与不健康的心脏结构和功能有关. 系统性血压和胰岛素抵抗是介导这些不良心血管影响的关键因素.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 医疗成像医学成像
背景情况:
- 不同的脂肪储存与心血管健康有不同的关联.
- 内脏脂肪组织 (VAT) 和肝脏脂肪积累越来越多地被认为对心脏代谢健康有害.
研究的目的:
- 通过心磁共振 (CMR) 测量腹部VAT和肝脂肪 (PDFF) 与心脏结构和功能的关联.
- 调查潜在的调解机制,包括血压,代谢因素和生物标志物,将脂肪储存与心脏结果联系起来.
主要方法:
- 利用了来自英国生物库的10,920名参与者的数据.
- 采用多重线性回归和调解分析来检查VAT/PDFF和CMR衍生的心脏指标之间的关系.
- 评估了与缩血压,糖尿病,失脂症和血液生物标志物的关联.
主要成果:
- 增加的VAT和PDFF与不良的左心室结构和功能受损有关,包括增加壁壁厚度和减少全球纵向应变.
- 增值税和PDFF的组合,特别是两者的高水平,与不良的心脏改造有关.
- 缩血压和甘油三糖指数部分介导了脂肪储存和心脏参数之间的关系.
结论:
- 内脏脂肪组织和肝脂肪独立地与有害的心脏结构和功能有关.
- 系统性血压和胰岛素抵抗成为脂肪与心脏关系中的重要调解因素.
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